Confirmation of the high degree of overlap between the MS-IFNB1 signature and the SLE datasets was demonstrated by the significant correlation (p < .0001) by linear regression to SLE WB, PBMC, and DLE datasets with coefficient of determination (r2) values of 0.51–0.65 (Supplementary Fig. 4). Here, IFNB1 is linked to systemic lupus erythematosus.