The MS-IFNB1 Z scores were higher than the PBMC-derived Z scores, but IFNW1, IFNA2, and IFNB1 were still highly significant (Z > 3) for all SLE WB, PBMC, and affected tissues, the control dermatomyositis dataset, but not the sepsis dataset. Here, IFNA2 is linked to systemic lupus erythematosus.