In particular, we found that genetic alterations of PIK3CA, RB1 and MDM2 were present in 24–28% of GBM unable to generate high-quality neoantigens and attract CD8+ T lymphocytes but only in 0–8% of GBM with high-quality neoantigens and high CD8+ T lymphocytes (RNA-seq, p = 0.06; Agilent, p = 0.02; Supplementary Table 5). Here, MDM2 is linked to glioblastoma.