The gene ontology enrichment map network (Q < 0.00001, normalized enrichment score, NES > 0.6) revealed that the most significant biological processes enriched in IDH wild-type GBM from both RNAseq and Agilent microarray datasets were immune response categories, thus providing additional evidence for the specific immune functions implemented within the tumors that contain high-quality neoantigens and high CD8+ T cells (Fig. 5a, b). This evidence concerns the gene CD8A and glioblastoma.