EGFR and lung carcinoma: Previous work in this field has shown that a germline deletion in BIM (BCL2L11), which alters RNA splicing and impairs the generation of the death-inducing isoform of BIM, is associated with resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs), such as gefitinib and erlotinib, in lung cancer.