Importantly, the proposed model focused on prostate cancer interactions with osteoblasts, osteocytes, and their respective ECM, due to the pathological relevance of osteoblastic lesions, yet some prostate cancer types present with mixed osteoblastic and osteolytic lesions.50 Osteoclasts indeed rely on RANKL, OPG, and matrix metalloproteinases, among others,51 which may all be expressed by prostate cancer cells, ultimately affecting the crosstalk with osteoblasts, in turn influencing the resulting predominant lesion type. This evidence concerns the gene TNFRSF11B and Familial prostate cancer.