SOST was the only gene upregulated in 2D and 3D in PCa-AD ( > 2.4-fold), in line with direct AR-mediated effect, with androgen deprivation leading to SOST increase.25 Overall, PCa-DHT led to similar response as in PCa-Norm in hOBMT, and similar between donors (Fig. 3d). This evidence concerns the gene SOST and posterior cortical atrophy.