In fact, SOST has an inhibitory effect on prostate cancer invasion,32 which induced lower rates of metastasis,49 and a lack of SOST within bone promotes expression of genes associated with cell migration/invasion.32 Finally, even when SOST expression was heightened by androgen deprivation, overall expression levels from co-cultures were kept low (C4-2B/hOBMT) or strongly downregulated (LNCaP/hOBMT), compared to monocultures. Here, SOST is linked to prostate cancer.