Overexpression of DMP1 in bone of B6 WT mice did not affect blood pressure, heart morphology, function or lifespan, but B6 Col4a3−/−/DMP1TG mice showed a near complete rescue of the LVH phenotype with similar parameters of cardiac morphology to B6 WT mice despite no change in severity of hypertension (Fig. 6a–j) or kidney function, and despite worsened hyperphosphatemia (Fig. 4, i, 4c). Here, DMP1 is linked to Hypertension.