Daily injections of DMP1 for one week in fast progressing 6-week-old 129 Sv Col4a3−/− mice with early CKD did not impact kidney function (Fig. 4k), but prevented the early significant rise in cFGF23 and the non-significant rise in iFGF23 (Fig. 4l–m). The gene discussed is COL4A3; the disease is chronic kidney disease.