COL4A3 and chronic kidney disease: The Col4a3−/− mice is an established model that displays many clinical features of human progressive CKD, including bone and mineral metabolism alterations, LVH when engineered on the B6 genetic background and early death.40 Impaired bone remodeling has been reported in previous studies in 129 Sv Col4a3−/− mice.31,37 In this study, we further show in both genetic backgrounds, a mild bone mineralization defect, and alterations in osteocyte morphology and networks.