In AML, the loss of the H3K27 methyltransferase EZH2 induced resistance to cytarabine,10 whereas in lymphoma models the loss of the H3K27 demethylase UTX sensitized the cells to this drug.5 It remains interesting to determine whether the above findings, if applied in clinics, could enhance the treatment outcome of UTX-deficient tumors. The gene discussed is KDM6A; the disease is acute myeloid leukemia.