KDM6A and lung carcinoma: UTX is an important epigenetic regulator, and many human cancers harbor mutations or deletions in this gene.2 A series of recent studies have established the role of UTX as a tumor suppressor in leukemia, lymphoma, pancreatic, and lung cancers.3–7 In particular, it was also demonstrated that UTX escapes from X chromosome inactivation, therefore females have more functional copies of this tumor suppressor than do males, and different dosages of UTX in male and females contribute to cancer sex bias.5,8