CAV1 and scleroderma: This correlation is especially pronounced in scleroderma,20 keloids,28 and HTS.29 Moreover, Cav-1−/− mice demonstrate significant shift in the synthesis/degradation balance of collagens towards an increase in net synthesis, which correlates with increased local density of myofibroblasts within the skin and the enhanced cell death and fibrosis observed in WAT.30