The result showed that loss of USP10 significantly decreased the expression of SKP2, as well as the phosphorylation and downstream signals of Bcr-Abl (Fig. 2h), suggesting that USP10 is required for the expression of SKP2 and the phosphorylation of Bcr-Abl in CML cells. This evidence concerns the gene USP10 and chronic myelogenous leukemia, BCR-ABL1 positive.