In the tumor model established using TE-1 cells, the tumor growth curves showed that knockdown expression of Nectin-4 significantly inhibited the tumor growth (Fig. 8d, P < 0.001), while the tumor growth of Nectin-4 over-expression group also trended to be faster than that of control group (Fig. 8d, P = 0.1816). Here, NECTIN4 is linked to neoplasm.