Moreover, based on the TCGA data from http://gepia.cancer-pku.cn/, we studied the mRNA expression levels of Nectin family members including Nectin-1, -2, -3 and -4 in human EC tissues, Fig. 2c shows that the mRNA expression level of Nectin-3 was significantly higher in cancer tissues compared with that in adjacent normal tissues (P < 0.05). Here, NECTIN1 is linked to cancer.