NECTIN4 and neoplasm: In the tumor model established using Eca-109 cells, the tumor growth curves showed that knockdown expression of Nectin-4 significantly inhibited the tumor growth (Fig. 8a, P < 0.0001), while the tumor growth of Nectin-4 over-expression group also trended to be faster than that of control group (Fig. 8a, P = 0.0831).