AR and pachyonychia congenita: We further investigated the ability of miR-346, 1361-3p and -197 to regulate proliferation of AR variant-driven PC cell lines, by comparing proliferation between parental 22RV1 cells (all variants and WT expressed) and WT-knock out derivatives (22RV1-AR-FL-KO), and also between parental CWR-R1-AD1 cells (lacking AR-v567es) and the CWR-R1-D567es derivative lacking WT-AR but overexpressing v567es.