AGO2 and colorectal cancer: This study is not the first to report miR-346 upregulation of target genes: miR-346 increases AGO2 mRNA and protein levels in cervical, gastric and colorectal cancer cell lines through formation of a miR-346 mid-region ‘bulge’ upon association with AGO2 3′UTR, which in turn increases recruitment of GRSF1 [35].