In addition to genes that are typically dysregulated in cancer cells after HDACi treatment, we observed changes in axolotl genes that regulate transcription and developmental signaling pathways (e.g. smad7, bmp2, id1, id2, notch1, jag1, dll1, prickle1, dact1, myc, mycn, ngfr, hes5, meis2, sox8, foxc1, lefty1, spry1). The gene discussed is NOTCH1; the disease is cancer.