Of these, JPH2 (Fig. 5A) and Tcap (Fig. 5B) showed no change in abundance with disease duration or tadalafil treatment whereas MTM1 abundance was increased equally above control in the 4-week tachypaced, HF and tadalafil treated animals (Fig. 5C, all p < 0.05). This evidence concerns the gene MTM1 and hydrops fetalis.