MYC and cancer: The concept that SNF5 is a coactivator for MYC, however, conflicts with its well-established role as a tumor suppressor, with a report that SNF5 and MYC oppositely regulate a common set of genes21, with findings that loss of SNF5 in cancer is associated with activation of MYC target gene signatures8–10, and with recent observations that MYC inhibition can restrict rhabdoid tumor growth in vivo23.