HIPK2 and cancer: Ingenuity pathway analysis (IPA) of the differentially expressed genes showed that Tet2/3 deficiency in Treg cells affected three main categories of canonical pathways (Fig. 4b and Supplementary Data 2): genes involved in DNA damage, DNA repair (Brca1, Atm, Rad50), and cell cycle (Cdkn1a, Cdkn2a, Hipk2) (green bars); genes implicated in immune cell function such as the antigen presentation pathway (H2-Aa, H2-Ab, and H2-Eb1), Th1 and Th2 activation pathways, etc (blue bars); and genes related to molecular mechanisms of cancer (orange bars).