In addition, we surveyed the LC domains of other members in the hnRNP family, including hnRNPA2, hnRNPDL, hnRNPH, hnRNPK, and hnRNPR, which were identified to be closely associated with different diseases, such as ALS, spinal muscular atrophy (SMA), and cancer31–34. The gene discussed is HNRNPR; the disease is amyotrophic lateral sclerosis.