The up-regulation of Fascin protein expression has been found in many cancers, such as esophageal carcinoma7, non-small cell lung cancer8, breast cancer9, gastric carcinoma10, pancreatic ductal adenocarcinoma11, ovarian cancer12, and adrenocortical carcinoma13, thus we hypothesized that Fascin might play a vital role in the malignant transformation of squamous cell epithelium14. This evidence concerns the gene FSCN1 and cancer.