As the up-regulation of Fascin protein expression has been confirmed in many cancers, such as esophagus carcinoma7, non-small cell lung cancer8, breast cancer9, gastric carcinoma10, pancreatic ductal adenocarcinoma11, ovarian cancer12, and adrenocortical carcinoma13, we hypothesized that FSCN1 might be a biomarker in TSCC. This evidence concerns the gene FSCN1 and cancer.