This observation is also supported by our findings that 3-DZNeP treatment resulted in E-cadherin preservation in the kidney of mice exposed to cisplatin, whereas, in H1299 cells, a NSCLC cell line with low expression of E-cadherin, 3-DZNeP application potentiates rather than ameliorates cisplatin-induced tumor cells killing. The gene discussed is CDH1; the disease is neoplasm.