Our results demonstrated that 3-DZNeP protects against cisplatin-induced tubular cell injury in cultured mouse renal proximal tubular epithelial cells (mTECs) and in a mouse model of cisplatin nephrotoxicity and enhances the cytotoxic effect of cisplatin in tumor cells (i.e. NSCLC cells) through a mechanism involving the upregulation of E-cadherin expression. The gene discussed is CDH1; the disease is neoplasm.