Although vascular defects had not been directly associated with human DYRK1A haploinsufficiency syndrome, it has been reported that nearly 75% of children with autism, some of which may have DYRK1A mutations or its reduced activity (Kim et al., 2017), exhibited hypoperfusion in the brain detected by neuroimaging (Bjorklund et al., 2018; Zilbovicius et al., 2000). This evidence concerns the gene DYRK1A and autism.