MITF and melanoma: MITF is closely linked with Wnt/β-catenin signaling, as it sequesters GSK3 and Axin1 which stabilize it and allow it to translocate to the nucleus where it promotes expression of many lysosomal genes, resulting in an expansion of multivesicular bodies (MVBS) and a consequent enhancement in Wnt signal, generating a positive feedback loop linked with melanoma progression.