The data presented here reveal that AIP is a positive regulator of BCL6 protein expression, which is commonly upregulated in B cell lymphomas, and show that AIP binds to an E3 ligase (FBXO11) and a DUB (UCHL1), both of which have been associated with DLBCL pathobiology. This evidence concerns the gene ZUP1 and B-cell non-Hodgkin lymphoma.