The data presented here reveal that AIP is a positive regulator of BCL6 protein expression, which is commonly upregulated in B cell lymphomas, and show that AIP binds to an E3 ligase (FBXO11) and a DUB (UCHL1), both of which have been associated with DLBCL pathobiology. Here, FBXO11 is linked to diffuse large B-cell lymphoma.