The current study indicates that the mitochondrial calcium uniporter is largely dispensable for BAT bioenergetics: the mouse model we used completely lacks uniporter activity in BAT, but displays no obvious abnormalities in cold tolerance, diet-induced obesity, BAT PDH phosphorylation, or BAT transcriptome-wide gene expression at baseline or in response to acute cold challenge. Here, PDP1 is linked to obesity due to melanocortin 4 receptor deficiency.