Physical activity has been shown to decrease the production of proinflammatory cytokines in adipose tissue by reducing obesity.34 Steensberg et al35 reported that increasing exercise contributed to the upregulation of IL‐6, which enhanced the level of antiinflammatory cytokines IL‐1α and IL‐10. The gene discussed is IL6; the disease is obesity due to melanocortin 4 receptor deficiency.