For example, amplification of the SOX2 gene has been reported in human squamous cell carcinomas (SCC) of the lung and esophagus, small-cell lung cancer (SCLC) and glioblastoma (Bass et al., 2009; Annovazzi et al., 2011; Rudin et al., 2012). This evidence concerns the gene SOX2 and small cell lung carcinoma.