While there are a number of mutations in different genes that can cause HGPS the most common mutation associated with “classical” HGPS is caused by a de novo mutation in the lamin A (LMNA) gene (De Sandre-Giovannoli, et al. 2003; Eriksson, et al. 2003). This evidence concerns the gene LMNA and Hutchinson-Gilford progeria syndrome.