Fucoidan (from Sargassum hemiphyllum) decreases the invasion activity of HCC cells (Huh6, Huh7, SK-Hep1 and HepG2 cells) via downregulation of the microRNA-29b-DNMT3B-MTSS1 axis and inhibition of TGF-β signaling [78]. This evidence concerns the gene DNMT3B and hepatocellular carcinoma.