In addition, fucoidan reduces tumor size in LLC1-xenograft male C57BL/6 mice and decreases tumor growth by modulating the TGFR/Smad7/Smurf2-dependent axis, leading to TGFR protein degradation and inhibition of lung cancer cell progression in vitro and in vivo [26]. The gene discussed is SMURF2; the disease is lung carcinoma.