Fucoidan-like polysaccharides (from Sargassum thunbergii) inhibit migration and angiogenesis (i.e., tube formation of endothelial cells) and suppress the migration and proliferation of lung cancer cells via reduction of MMP-2 enzymatic activity, expression at the transcriptional level, and downregulation of VEGF and HIF-1α expression [77]. The gene discussed is HIF1A; the disease is lung cancer.