Fucoidan from Cladosiphon okamuranus (Okinawa Mozuku) inhibits human gastric adenocarcinoma cell line MKN45 proliferation by suppressing the ASK1 (apoptosis signal-regulating kinase)-p38 signaling pathway through reduction of phosphorylated ASK1 levels [45]. This evidence concerns the gene MAP3K5 and gastric adenocarcinoma.