ANGPT2 and fetal growth restriction: However, ANGPT2 gene was found to be downregulated in the placenta of the AGA twin from the IUGR/AGA pregnancy compared to the two AGA twins in the AGA/AGA pregnancy; whereas, the placentas of SGA (IUGR) fetuses demonstrated similar expression to the AGA fetuses from the AGA/AGA pregnancies (Fig. 3a).