GLIS3 and diabetes mellitus: Some case studies indicate that patients with a GLIS3 gene mutation resulting in a truncated non-functional protein demonstrated IUGR (Dimitri et al. 2011).In addition, patients with disturbances in the GLIS3 gene demonstrate impaired beta cell function and an altered fasting glucose and diabetes mellitus phenotype (Wen and Yang 2017; Yang et al. 2013).