In particular, extracellular ATP can activate the caspase-1 dependent NLRP3 complex (the so called inflammasome) triggering IL-1β secretion (Ghiringhelli et al., 2009), which in turn promotes CD8+ T cell (Ghiringhelli et al., 2009), as well as, IL-17 producing-γδ T cell (Ma et al., 2011) anti-tumor responses. Here, CD8A is linked to neoplasm.