ARID1A and cancer: Along with these highly prevalent alterations known to be present in an array of cancer types, there were many canonical oncogenic pathway mutations detected, including gain of function mutations in oncogenes (EGFR 11%, PIK3CA 16%) and loss of function mutations in tumor suppressor genes (PTEN 11%, ARID1A 8%, APC 6%) [37, 38, 41].