All CD138.CAR-Ts generated from healthy donors, irrespective of the CAR construct, lysed the CD138+ MM cell lines OPM-2, U266-B1, RPMI-8226, and MM.1S, at a significantly higher rate as compared to control T-cells (Ctr-Ts), while leaving CD138− targets (Raji) unaffected (Figure 2A, 2B). This evidence concerns the gene SDC1 and Miyoshi myopathy.