Consistent with data from the two tumor models described above, Figure 6A shows that in the Tu-2449SC tumor model, mice bearing tumor with as low as 2% Tu-2449SC cells expressing scFv PD-L1 led to a delay in tumor progression that is comparable to anti-PD-1 antibody treatment, but not statistically significant when compared to untreated mice (Figure 6A). The gene discussed is CD274; the disease is neoplasm.