When relying on three M1 and three M2 markers via qPCR of the CD11b fraction, we were able to correlate the M1-M2 TAM distribution with clinical NFPA behavior, underscoring the importance of analyzing these fractions via multiple antigens because the M1-M2 distribution may be a continuous spectrum rather than dichotomous extremes [13]. The gene discussed is ITGAM; the disease is non-functioning pituitary adenoma.