MYCN and neuroblastoma: As shown in Figure 2A, JQ1 treatment (0.5 μM for 48 or 72 hours for both SH-SY5Y and LA-N-5, and 0.5 μM for 24 or 48 hours for IMR-32) efficiently downregulated MYCN in all NB cell lines, with more evident effects on both MNA LA-N-5 and IMR-32 cell lines.