In addition, PHF14 was involved in AKT-mTOR-4E-BP1 signaling pathway and expression level of PHF14 was positively correlated with several key translation factors in TCGA skin and colon cancer patient dataset, indicated that hypoxia-mediated suppression of PHF14 gene is related with cellular protein synthesis under stress condition. This evidence concerns the gene AKT1 and malignant colon neoplasm.