TNF and cancer: The top 10 enriched pathways implicated in the in-vitro analysis of SP3 vs. NSP2 included: Proteoglycans in cancer, Tumor necrosis factor (TNF) signaling pathway, Toll-like receptor signaling pathway, cGMP-PKG signaling pathway, Thyroid hormone signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Viral carcinogenesis, Aldosterone-regulated sodium reabsorption and Carbohydrate digestion/absorption (Figure 5D).