SP3 and prion disease: The top 10 enriched pathways implicated in the in-vitro analysis, of SP3 vs. NSP2 included: ECM-receptor interaction, Focal adhesion, Complement and coagulation cascades, Protein digestion and absorption, Cytokine-Cytokine receptor interaction, Pathways in cancer, Prion disease, Hematopoietic cell lineage, TGF-beta signaling pathway and Amoebiasis (Figure 7D).