Interestingly, we also show Cyclin D1 and Activator Protein 1 (AP1) via GO and KEGG pathway analysis, overexpression, to be associated with altered estrogen signaling pathway regulation [34] and MDS1/ EVI1 complex locus (Mecom), overexpression, able to modify cellular insensitivity to anti-growth signals, in tumor initiation [35]. The gene discussed is MECOM; the disease is neoplasm.