Although it has been known for more than 30 years, much remains to be learned about the NFκB pathway, the crosstalk between the canonical and non-canonical NFκB pathways, the interaction of the NFκB pathway with other signal transduction pathways, and the NIK-, IKK-, and NEMO-dependent but NFκB-proteins independent effects in the gene regulation of renal diseases. Here, NFKB1 is linked to kidney disorder.