NFKB1 and kidney disorder: The crosstalk between canonical and non-canonical NFκB signaling in the complex regulation of Th17 cells and Tregs warrants further investigation to identify potent candidate genes for the manipulation of pathogenicity of Th17 cells without affecting nonpathogenic Th17 and Treg cells that may be critical for tissue homeostasis in renal diseases (109, 142, 143) (Figure 2).