According to experiments of depletion with monoclonal antibodies, the cross-efficacy against the infection by L. (L.)amazonensis is based on a CD4+ T cell-driven response against the C-terminal domain that determines a 75% reduction of the lesion sizes, and on a CD8+ T cell response against the N-terminal domain of NH36, that reduced the lesions by 57% (10). Here, CD4 is linked to infection.