Epigenomics has further suggested that specific DNA methylation changes in lupus CD4+ T cells are correlated with different clinical phenotypes of SLE such as skin lesions only, skin and renal involvement only, and skin and renal involvement with polyarticular disease, while there are also common methylation changes found in all groups of SLE compared to controls (77). The gene discussed is CD4; the disease is systemic lupus erythematosus.