The signature generated by these miRNAs allowed to identify APS patients with a marked accuracy (AUC of 0.81), was found associated to the presence of both, fetal loss and type of thrombosis, and correlated with parameters related to inflammation and thrombosis (TF, PAI-1, VEGF-A, VEGF-R1, and MCP-1). Here, SERPINE1 is linked to autoimmune polyendocrinopathy.