Multiple molecules, essential in the hemostatic system, and acting as key players in thrombosis and atherosclerosis development, are altered in APS immune and vascular cells by effect of aPLs, including TF, the VEGF/Flt1 axis, several toll-like receptors (TLRs), annexins, protein disulfide isomerase, etc. Here, VEGFA is linked to autoimmune polyendocrinopathy.