They found that sixteen genes (CXCL4L1, P-Selectin, TLR2, TLR4, PAI-1, β2GPI, GP1a, GP1BA, PAR1, PAR2, TFPI, TF, VEGFA, FLT1, TNF, and Prothrombin) contribute significantly, while six (PLSCR1, PTPN22, ACAPMTS13, F13A1, ACE, and F5) were not associated with thrombosis in primary APS. Here, TLR4 is linked to autoimmune polyendocrinopathy.