LncRNAs, such as ASMER-1 and ASMER-2, have been proposed as key players in the insulin resistance associated with obesity (72) and as being involved in the potential mechanism in the link between obesity and cancer (73).In short, in recent years, numerous studies have been focusing on epigenetics as a link between environmental factors and a greater predisposition to the development of obesity and its comorbidities (17). Here, ASMER1 is linked to obesity due to melanocortin 4 receptor deficiency.