CLOCK and cancer: and rats (Woon et al., 2006; Hughes et al., 2012; Summa et al., 2012; Kuintzle et al., 2017; Matsumura and Akashi, 2017), but sparsely used in humans due to disease heterogeneity, patient uniqueness, health care affordability, overwhelm of data which is left unanalyzed in the absence of adequate expertise, etc. Genomic sequencing has been used to identify the circadian gene CLOCK as mutated in other epithelial gastro-intestinal (GI)-derived cancers, such as colorectal cancer (Alhopuro et al., 2010).