AKT1 and head and neck squamous cell carcinoma: Other studies have undertaken a comprehensive molecular multi-layered omics-based approach applied to a single HNSCC-derived cell line and its single-cell derived subclones, to elucidate the tumor heterogeneity and treatment-induced clonal selection (Niehr et al., 2018) or a single signaling pathway (e.g., AKT/PKB) (Fruman et al., 2017; Manning and Toker, 2017).