G6PD and Hemolytic anemia due to red cell pyruvate kinase deficiency: Thus, within the CoMMiTMenT project, by direct RBCs electrophysiological measurements in physiological solutions, we aimed to investigate whether RBC membrane conductance changes are accompanying HS due to mutations in the SPTA1 gene (coding for α-spectrin), SPTB (β-spectrin), ANK1 (ankyrin), and SLC4A1 (band 3 protein); HX due to mutations in PIEZO1; enzymatic disorders due to glucose-6-phosphate dehydrogenase deficiency (G6PD), pyruvate kinase deficiency (PKD), glutamate-cysteine ligase (γ-glutamylcysteine synthetase) (GCL) deficiency, glutathione reductase deficiency and β-thalassemia.