Finally, NMDA receptor-mediated signaling genes, such as D-amino acid oxidase (DAO), protein phosphatase 3 catalytic subunit gamma isoform (PPP3CC), and dystrobrevin-binding protein 1 (DTNBP1) genes, were associated with both the pathogenic mechanisms of and antipsychotic treatment response in schizophrenia (Reynolds, 2012b; Sacchetti et al., 2013). This evidence concerns the gene DAO and schizophrenia.