A study by Blasi et al. (2013) showed that rs6314 of the 5-HT2A gene affects 5-HT2AR expression and functionally contributes to the genetic modulation of endophenotypes of schizophrenia, such as higher-level cognitive behaviors and related prefrontal activity, as well as to olanzapine response. This evidence concerns the gene HTR2A and schizophrenia.