Likewise, previous study manifests that apelin-13 exerts a protective role for neurons against cerebral ischemia/reperfusion (I/R) injury through inhibiting the expression of inflammatory factors (IL-1β, TNF-α, and ICAM-I) and the activation of microglia and astrocytes (Xin et al., 2015). This evidence concerns the gene IL1B and Cerebral ischemia.