YAP1 and neuroblastoma: As both our WMG-1 (Szemes et al., 2018) and MES (van Groningen et al., 2017) signatures are associated with Hippo-YAP/TAZ, it may be inferred that Hippo signaling, which has been implicated in NB tumorigenesis (Wang et al., 2015; Yang et al., 2017), may, at least at diagnosis, not be integral to high-risk neuroblastoma.