WWTR1 and neuroblastoma: By converting the expression of each of the four gene subsets into a numerical model, or metagene, we were further able to show that, for example, expression of Wnt metagene 1 (WMG-1) strongly positively correlated with Hippo-YAP/TAZ signaling signatures (R = >0.76) in NB, and that these genes were more highly expressed in intermediate risk NB, rather than low- or high-risk NB.