As our RNA sequencing of the NB cell line SK-N-BE(2)-C treated with Wnt3a/Rspo2 provides a unique gene set representing, at least in part, Wnt targets in the NC, we assessed which GRN genes encoding transcription factors or signaling molecules from different stages of NC development might be affected by Wnt3a/Rspo2 treatment (Table 1). This evidence concerns the gene RSPO2 and neuroblastoma.