NFE2L2 and Alzheimer disease: Furthermore, Nrf2-mediated neuroprotection is primarily conferred by astroglia both in vitro and in vivo (Liddell, 2017) and in AD patients, Nrf2 expression is decreased in both hippocampal neurons and astrocytes (Ramsey et al., 2007) indicating a strong involvement of Nrf2 signaling in neurodegeneration and neuronal function.