NFE2L2 and Alzheimer disease: Previous work has shown that activation of the Nrf2/Keap1 transcriptional pathways can protect hippocampal neurons from Aβ-induced neurodegeneration in an AD mouse model (Lipton et al., 2016) and rescue neuronal deficiencies in various models for PD (Johnson and Johnson, 2015), confirming a protective role in neuronal function with potential for therapeutic treatments.