To investigate the cancer-stromal interactions through ERRα in endometrial cancer, human endometrial fibroblasts immortalized with human telomerase reverse transcriptase (T-HESCs) were co-cultured with Ishikawa or HEC-1A cells overexpressing ERRα/PGC-1α (Fig. 1B). The gene discussed is PPARGC1A; the disease is endometrial cancer.