ESR1 and hemorrhagic stroke: Because the constitutive mRNA and protein levels of ERα, but not ERβ, in the striatum are higher in female than in male rats7, we prospect high level of endogenous E2 may protect against hemorrhagic stroke predominantly via ERα in females, while, in males, other ERs may mediate the neuroprotection conferred by E2 against FC-induced striatal injury.