The overexpression of the DnGR prevented the effects of DEX-induced cognitive impairment in EAE animals, confirming that GR can impair the learning and consolidation of working memory at 2 (P = 0,0087) and 24 hours (P = 0,0152) after training (Fig. 7B–D). This evidence concerns the gene NR3C1 and Cognitive impairment.