GLA and Fabry disease: We used the α-galactosidase A (GLA) as a representative ERT in a mouse model of Fabry disease, and demonstrate how distinct glycoforms of GLA are differentially targeted to liver, spleen, kidney, and heart, and present evidence that GLA glycoforms capped with α2-3-linked SA (α2-3SA), but surprisingly not α2-6SA, exhibit improved circulation and biodistribution.