Moreover, the observation that DS-associated increased levels mitochondrial superoxide is blunted by GLP-1 (9-36) treatment agrees with a body of evidence linking mitochondrial ROS to aging-related cognitive and synatpic pathology (Massaad and Klann, 2011; Wang et al., 2014; Guo et al., 2017). The gene discussed is GCG; the disease is Dravet syndrome.