The chromatin-modifying genes CREBBP (mutated in 30% of GCB-DLBCL [11], in early FL stages [62] and shared between primary and transformed FL [63]) and KMT2D (alias MLL2) are located in spots up- or downregulated in part of the FL cases compared with DLBCL suggesting epigenetic deregulation in FL. Here, CREBBP is linked to diffuse large B-cell lymphoma.